Many thanks to Sergiu Groppa as Co-Editor and to all co-authors for the great involvement and excellent content. We focus on recent advances and translational paths and methods to study central inflammation and adress ongoing pathophysiological processes and the transition between inflammation and neurodegeneration. We provide useful information for conceptual and experimental work and hope a lot that the book will be of great help for many colleagues. Enjoy & comment! tinyurl.com/yjpahoch